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PubMed COVID-19 Clinical Care

17021 - 17030 of 57354 results found

Pyrazolidinone-Based Peptidomimetic SARS-CoV-2 Mpro inhibitors

Date
Sunday, October 22, 2023 - 4:00 AM
Description
The main protease (M^(pro)) of SARS-CoV-2 is an attractive drug target for COVID-19 treatment as it plays an integral role in the proliferation of coronavirus. Herein, we describe the investigation of β- and γ-lactams as electrophilic "warheads" for

Increasing antiretroviral therapy adherence and retention in care among adults living with HIV in Philadelphia: a study protocol for a stepped-wedge cluster-randomised type 2 hybrid effectiveness-implementation trial of managed problem-solving plus (MA...

Date
Saturday, October 21, 2023 - 4:00 AM
Description
INTRODUCTION: To end the HIV epidemic in Philadelphia, implementation of evidence-based practices (EBP) to increase viral suppression and retention in HIV care is critical. Managed problem solving (MAPS), an EBP for antiretroviral therapy adherence